国際先導研究

総説

2025年

  1. 酒井　勁，関根弘樹，本橋ほづみ．
    レドックス制御とフェロトーシス感受性．
    実験医学43 (9) ６月号　1343-1347, 2025.　doi:10.18958/7737-00001-0006027-00
  2. Sekine H, Akaike T, Motohashi H.
    Oxygen needs sulfur, sulfur needs oxygen: a relationship of interdependence.
    EMBO J. 2025 Jun;44(12):3307-3326. doi: 10.1038/s44318-025-00464-7.
  3. Cuadrado A, Cazalla E, Bach A, Bathish B, Naidu SD, DeNicola GM, Dinkova-Kostova AT, Fernández-Ginés R, Grochot-Przeczek A, Hayes JD, Kensler TW, León R, Liby KT, López MG, Manda G, Shivakumar AK, Hakomäki H, Moerland JA, Motohashi H, Rojo AI, Sykiotis GP, Taguchi K, Valverde ÁM, Yamamoto M, Levonen AL.
    Health position paper and redox perspectives - Bench to bedside transition for. pharmacological regulation of NRF2 in noncommunicable diseases.
    Redox Biol. 2025 Apr;81:103569. doi: 10.1016/j.redox.2025.103569.
  4. Braunstein I, Motohashi H, Dallenga T, Schaible UE, Benhar M.
    Redox signaling in innate immunity and inflammation: focus on macrophages and neutrophils.
    Free Rad Biol Med 237, 427-454, 2025.
  5. 尾股　明，赤池孝章，本橋ほづみ．
    新たな生体分子「超硫黄」の発見とその機能．
    臨床免疫・アレルギー科 84 (2)　130-137, 2025.
  6. Zhang T, Pan Y, Sawa T, Akaike T, Matsunaga T.
    Supersulfide donors and their therapeutic targets in inflammatory diseases.
    Front Immunol. 2025 Apr 16;16:1581385. doi: 10.3389/fimmu.2025.1581385.
  7. Zhang T, Toyomoto T, Sawa T, Akaike T, Matsunaga T.
    Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases.
    Microbiol Immunol. 2025 Apr;69(4):191-202. doi: 10.1111/1348-0421.13205.
  8. Mi X, Wu D, Ito T, Kato Y, Nishimura A, Nishida M*.
    TRP channels in cardiac mechano-redox coupling and diseases.
    J. Cardiol. https://doi.org/10.1016/j.jjcc.2025.02.016.

2024年

  1. 松永哲郎, 張 田力, 赤池孝章
    呼吸器ウイルス感染症と呼気オミックス
    臨床免疫・アレルギー科 Vol. 82, No. 3, 312-317 (2024)
  2. 緒方星陵, 松永哲郎, 赤池孝章
    超硫黄分子による呼吸器疾患制御と呼気オミックス
    呼吸器疾患最新の治療 2025-2026・南江堂
  3. 緒方星陵, Uladzimir Barayeu, 赤池孝章
    超硫黄分子の化学と生理機能
    酸化ストレスの医学 改訂第３版・診断と治療社
  4. Yoshiro Saito, Noriko Noguchi, Etsuo Niki.
    Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides.
    Free Radical Biology and Medicine, 211 (2024), 89–95 (2023)　
    DOI: https://doi.org/10.1016/j.freeradbiomed.2023.12.011
  5. Kazuhiro Nishiyama, Takashi Toyama.
    Supersulfides in Environmental Toxicology and Hygiene.
    YAKUGAKU ZASSHI, 144(1), 39-40 (2024)　
    DOI: https://doi.org/10.1248/yakushi.23-00162-F
  6. Takashi Toyama,Runa Kudo, and Yoshiro Saito.
    The Role of Supersulfide in Methylmercury Detoxification.
    YAKUGAKU ZASSHI, 144(1), 41-45 (2024)　
    DOI: https://doi.org/10.1248/yakushi.23-00162-1
  7. 有澤琴子、 外山喬士、 斎藤芳郎.
    スルフォラファンによるセレノプロテインP抑制と糖尿病予防への可能性.
    機能性食品と薬理栄養, 18(1), 29-34 (2024)　DOI:
  8. 外山 喬士，斎藤 芳郎.
    親電子性植物成分スルホラファンによるNrf2非依存的なセレノプロテインP発現低下機構.
    日本生化学会誌, 96(4), 567‒570 (2024)　
    DOI: https://doi.org/10.14952/SEIKAGAKU.2024.960567
  9. Sekine H, Motohashi H. Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulation.
    J Clin Biochem Nutr. 2024 Mar;74(2):91-96. doi: 10.3164/jcbn.23-106.　
  10. 河口まどか、本橋ほづみ．
    環境ストレス応答と硫黄代謝．
    臨床免疫・アレルギー科　81(4)、396-402、2024.
  11. Hayashi M, Okazaki K, Papagiannakopoulos T*, Motohashi H*.
    The complex roles of redox and antioxidant biology in cancer.
    Cold Spring Harb Perspect Med. 2024 May 21:a041546. doi: 10.1101/cshperspect.a041546.
  12. Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M.
    Ferroptosis in health and disease.
    Redox Biology, 75, 103211 (2024)　DOI: https://doi.org/10.1016/j.redox.2024.103211
  13. Akaike T, Morita M, Ogata S, Yoshitake J, Jung M, Sekine H, Motohashi H, Barayeu U, Matsunaga T.
    New aspects of redox signaling mediated by supersulfides in health and disease.
    Free Radic Biol Med. 2024 Jul 9;222:539-551. doi: 10.1016/j.freeradbiomed.2024.07.007.
  14. Nishimura A, Tang X, Zhou L, Ito T, Kato Y, Nishida M*.
    Sulfur metabolism as a new therapeutic target of heart failure.
    J Pharmacol Sci. 2024 Jul;155(3):75-83. doi: 10.1016/j.jphs.2024.04.005.
  15. Nishida M*, Mi X, Ishii Y, Kato Y, Nishimura A.
    Cardiac Remodeling: Novel Pathophysiological Mechanisms and Therapeutic Strategies.
    J Biochem. 2024 Mar 20:mvae031. doi: 10.1093/jb/mvae031.
  16. Hisashi Ohno, Shun Sumitani, Eita Sasaki, Sota Yamada, Kenjiro Hanaoka
    “Recent advances in fluorogenic probes based on twisted intramolecular charge transfer (TICT) for live-cell imaging”
    Chemical Communications, in press.
  17. Hisashi Ohno, Eita Sasaki, Sota Yamada, Kenjiro Hanaoka
    “Recent advances in Si-rhodamine-based fluorescence probes for live-cell imaging”
    Organic & Biomolecular Chemistry, 22, 3099-3108 (2024).
  18. J. Marszalek, R. Ushioda, H. Kampinga* et al.:
    J-domain proteins: From molecular mechanisms to diseases,
    Cell Stress and Chaperones 29 (1): 21-33 (2024)
  19. 小川亜希子、魏范研、
    「RNAの代謝と細胞外での役割」
    生化学96(6): 824-828 (2024)
  20. Tsutsuki H, Zhang T, Akaike T, Sawa T.
    Regulation of innate immune and inflammatory responses by supersulfides.
    Int Immunol. 2024 Mar 9;36(4):143-154. doi: 10.1093/intimm/dxad057.

2023年

  1. 赤池孝章（特集編集）
    ［特集］環境化学物質と生体応答
    Medical Science Digest Vol.49, No.1, 1-58 (2023)
  2. 松永哲郎、赤池孝章
    環境物質と生命の起源：超硫黄生物学プロローグ
    Medical Science Digest Vol.49, No.1, 3-9 (2023)
  3. 有澤 琴子, 外山 喬士, 斎藤 芳郎.
    必須微量元素セレン研究の最前線　ダイナミクスと生理／病理的意義、重金属毒性に対する作用.
    ファルマシア, 59(3), 179-184 (2023)　
    DOI: https://doi.org/10.14894/faruawpsj.59.3_179
  4. Noriko Noguchi, Yoshiro Saito, and Etsuo Niki.
    Actions of Thiols, Persulfides, and Polysulfides as Free Radical Scavenging Antioxidants.
    Antioxidants and Redox Signaling, 39(10-12), 728-743 (2023)　
    DOI: https://doi.org/10.1089/ars.2022.0191
  5. Yo Shinoda, Masahiro Akiyama, Takashi Toyama.
    Potential Association between Methylmercury Neurotoxicity and Inflammation.
    Biological and Pharmaceutical Bulletin, 46 (9), 1162-1168 (2023)　
    DOI: https://doi.org/10.1248/bpb.b23-00075
  6. 本橋ほづみ．
    環境化学物質に対する生体応答を担う転写制御．特集「環境科学物質と生体応答」
    Medical Science Digest 49 (1), 677-680, 2023.
  7. 村上昌平、成恩圭、本橋ほづみ．
    NRF2活性化による抗老化作用に関わる分子機構．特集「抗老化医療の、未来をさぐる：哺乳類における老化・寿命制御の理解とその社会実装」
    老年医学　61(1)、55-61、2023.　　
  8. 草野佑典、村上昌平、本橋ほづみ．
    エネルギー代謝におけるKEAP1-NRF2制御系と硫黄代謝の役割．
    化学と生物61 (4), 188-195, 2023.
  9. Murakami S, Kusano Y, Okazaki K, Akaike T, Motohashi H.
    NRF2 signalling in cytoprotection and metabolism.
    Br J Pharmacol. 2023 Sep 15. doi: 10.1111/bph.16246.
  10. Barayeu U, Sawa T, Nishida M, Wei FY, Motohashi H, Akaike T.
    Supersulfide biology and translational medicine for disease control.
    Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16271.
  11. Barayeu U, Sawa T, Nishida M, Wei FY, Motohashi H, Akaike T.
    Supersulfide biology and translational medicine for disease control.
    Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16271.