国際先導研究

原著論文

2025年

  1. Sekine H, Akaike T, Motohashi H.
    Oxygen needs sulfur, sulfur needs oxygen: a relationship of interdependence.
    EMBO J. 44: 3307-3326 (2025)
  2. Tayama S, Kitamura Y, Hiraide K, Suzuki H, Li J, Yang Z, Mitsuwaka R, Kawajiri A, Sato K, Gao F, Nakai T, Okuyama Y, Numakura T, Yamada M, Ida T, Morita M, Kawabe T, Akaike T, Ishii N.
    Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation.
    Front Immunol. 16: 1506580 (2025)
  3. Morishima T, Fakruddin M, Kanamori Y, Masuda T, Ogawa A, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Moroishi T, Tomizawa K, Suda T, Wei FY, Takizawa H.
    Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis.
    Sci Adv. 11: eadu3011 (2025)
  4. Zhang T, Toyomoto T, Sawa T, Akaike T, Matsunaga T.
    Supersulfides: A promising therapeutic approach for autoinflammatory diseases.
    Microbiol Immunol. 69: 191-202 (2025)
  5. Maemura M, Morita M, Ogata S, Miyamoto Y, Ida T, Shibusaka K, Negishi S, Hosonuma M, Saito T, Yoshitake J, Takata T, Matsunaga T, Mishima E, Barayeu U, Akaike T, Yano F.
    Supersulfides contribute to joint homeostasis and bone regeneration.
    Redox Biol. 81: 103545 (2025)
  6. Nishimura A, Tanaka T, Shimoda K, Ida T, Sasaki S, Umezawa K, Imamura H, Urano Y, Ichinose F, Kaneko T, Akaike T, Nishida M.
    Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides.
    Redox Biol. 79: 103445 (2025)
  7. Pan Y, Matsunaga T, Zhang T, Akaike T.
    The therapeutic potential of supersulfides in oxidative stress-related diseases.
    Biomolecules. 15: 172 (2025)
  8. Nishimura A, Ogata S, Tang X, Hengphasatporn K, Umezawa K, Sanbo M, Hirabayashi M, Kato Y, Ibuki Y, Kumagai Y, Kobayashi K, Kanda Y, Urano Y, Shigeta Y, Akaike T, Nishida M.
    Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice.
    Nat Commun. 16: 276 (2025), doi: 10.1038/s41467-024-55661-5.
  9. Zhang T, Pan Y, Sawa T, Akaike T, Matsunaga T.
    Supersulfide donors and their therapeutic targets in inflammatory diseases.
    Front Immunol. 16: 1581385 (2025)
  10. Mineshi Sakamoto, Masumi Marumoto, Koichi Haraguchi, Takashi Toyama, Yoshiro Saito, Steven J. Balogh, Chiharu Tohyama, and Masaaki Nakamura.
    Assessing the role of selenium in Minamata disease through reanalysis of historical samples.
    Environmental International,195(2025),109242(2024)　
    DOI:https://doi.org/10.1016/j.envint.2024.109242
  11. Xinying Ye, Takashi Toyama, Wang Yinuo, Runa Kudo, Siu Stephanie, Kotoko Arisawa, Yoshiro Saito.
    Inhibition of selenium supply function of selenoprotein p through adduct formation by sulforaphane.
    The Journal of Nutritional Biochemistry , 135(2025), 109781 (2025)
    DOI:https://doi.org/10.1016/j.jnutbio.2024.109781
  12. Hein Ko Oo, Cynthia M Galicia-Medina, Takumi Nishiuchi, Ryota Tanida, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Yoshiro Saito, Hiroaki Takayama, Toshinari Takamura.
    Cysteine redoxome landscape in mouse brown adipose tissue under acute cold exposure.
    iScience, 28, 3 (2025)　
    DOI:https://doi.org/10.1016/j.isci.2025.112051
  13. Atsuya Ichikawa, Takashi Toyama, Hiroki Taguchi, Satoru Shiina, Hayato Takashima, Kazuaki Takahashi, Yasumitsu Ogra, Ayako Mizuno, Kotoko Arisawa, Yoshiro Saito.
    The selenoprotein P/ApoER2 axis facilitates selenium accumulation in selenoprotein P-accepting cells and confers prolonged resistance to ferroptosis.
    Redox Biology, 83, 103664 (2025)　
    DOI:https://doi.org/10.1016/j.redox.2025.103664
  14. Yoshiro Saito, Misaki Shimizu, Mitsuharu Sato, An Masuda, Kotoko Arisawa, Keiko Taguchi, Takashi Toyama, Ikuko N. Motoike, Kengo Kinoshita, Seizo Koshiba, Masayuki Yamamoto & Toshinari Takamura.
    Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study.
    Scientific Reports, 25319 (2025)　
    DOI: https://doi.org/10.1038/s41598-025-10581-2
  15. Arai, K., Ono, Y., Hirai, N., Sugiura, Y., Kaneko, K., Matsuda, S., Iio, K., Kajino, K., Saitoh, T., Wei, F. Y., Katagiri, H., & Inoue, A.
    Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity. Biochimica et biophysica acta.
    Molecular basis of disease, 1871(2), 167566 (2025).
  16. Matsuda, S., Nakayama, M., Do, Y., Ishiuchi, T., Yagi, M., Wanrooij, S., Nakada, K., Wei, F. Y., Ichiyanagi, K., Sasaki, H., Kang, D., & Yasukawa, T.
    TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA.
    Communications biology, 8(1), 202 (2025)
  17. Tejima, M., Hashimoto, T., Ohno, O., Hoshina, T., Takasaki, K., Taniguchi, S., Nakamura, K., Wei, F. Y., Tomizawa, K., & Matsuno, K.
    Eperisone Analogs, Rescuers of MiaB Defects As a Prokaryotic Homologue of CDKAL1, Suppress Blood Glucose Elevation in Rats.
    ACS medicinal chemistry letters, 16(2), 311–316 (2025).
  18. Kouga, T., Miwa, T., Wei, F. Y., Sunami, K., & Tomizawa, K.
    Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs.
    Frontiers in cellular neuroscience, 19, 1541347 (2025).
  19. Su C, Mi X, Ito T, Kato Y, Nishimura A, Nagata R, Mori Y, Nishida M*.
    TRPC6-mediated Zn2+ influx negatively regulates contractile differentiation of vascular smooth muscle cells.
    Biomolecules 2025, 15(2), 267; https://doi.org/10.3390/biom15020267.
  20. Nishimura A, Nishiyama K, Ito T, Mi X, Kato Y, Inoue A, Aoki J, Nishida M*.
    Ligand-independent spontaneous activation of purinergic P2Y6 receptor under cell culture soft substrate.
    Cells 2025, 14(3), 216; https://doi.org/10.3390/cells14030216
  21. Yoshikazu Fuse, Eita Sasaki, Masaharu Tamaki, Shunto Kawamura, Hisashi Ohno, Sota Yamada, Masahiro Yasunaga, Hideo Takakura, Hirofumi Hanaoka, Hisataka Kobayashi, Hideki Nakasone, Kenjiro Hanaoka “Development of a Silicon Phthalocyanine Analogue for Near-Infrared Photoimmunotherapy and its Application to HTLV-1-infected Leukemic Cells”
    Chemical Biology, in press.
  22. Hisashi Ohno, Shun Sumitani, Ariunbold Chuluun-Erdene, Takahiro Kuchimaru, Sota Yamada, Eita Sasaki, Kenjiro Hanaoka
    “Development of a near-infrared fluorescence probe for hypochlorous acid based on the phenyl-induced twisted intramolecular charge transfer (p-TICT) mechanism”
    Chemical Communications, 61, 10522-10525 (2025).
  23. Asamitsu S, Ozawa Y, Okamoto H, Ogata S, Matsunaga T, Yoshitake J, Fusegawa K, Taniyama Y, Sato C, Ishida H, Abe T, Motohashi H, Akaike T, Kamei T.
    Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer.
    Cancer Sci. 116 (4), 1023-1033, 2025. doi: 10.1111/cas.16430.
  24. Y. Takano, Y. Ishikawa-Kimata, R. Ushioda, Y. Kimata, K. Nakatsukasa*
    Hydroxyurea modulates thiol–disulfide homeostasis in the yeast endoplasmic reticulum:
    Life Science Alliance, 8(8):e202503225 (2025)
  25. AI-driven mechanistic analysis of conformational dynamics in CNNM/CorC Mg2+transporters.
    Ma J, Song X, Funato Y, Teng X, Huang Y, *Miki H, *Wang W, *Hattori M.
    Structure. 2025 Jan 2;33(1):104-114.e3.

2024年

  1. Roy B, Shieh M, Takata T, Jung M, Das E, Xu S, Akaike T, Xian M.
    Phototriggered hydrogen persulfide donors via hydrosulfide radical formation enhancing the. reactive sulfur metabolome in cells.
    J Am Chem Soc. 146: 30502-30509 (2024)
  2. Kondo M, Nakamura Y, Kato Y, Nishimura A, Fukata M, Moriyama S, Ito T, Umezawa K, Urano Y, Akaike T, Akashi K, Kanda Y, Nishida M.
    Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS. cell-derived cardiomyocytes.
    J Pharmacol Sci. 156: 69-76 (2024)
  3. Suzuki J, Hemmi T, Ida T, Ogata S, Yoshitake J, Matsunaga T, Ishida T, Numano Y, Kusano Y, Ikeda R, Nomura K, Sugawara M, Ohta N, Akaike T, Katori Y.
    Supersulfide formation in the sinus mucosa of chronic rhinosinusitis.
    Laryngoscope Investig Otolaryngol. 9: e1261 (2024)
  4. Akaike T, Morita M, Ogata S, Yoshitake J, Jung M, Sekine H, Motohashi H, Barayeu U, Matsunaga T.
    New aspects of redox signaling mediated by supersulfides in health and disease.
    Free Radic Biol Med. 222: 539-551 (2024)
  5. Majtan T, Olsen T, Sokolova J, Krijt J, Křížková M, Ida T, Ditrói T, Hansikova H, Vit O, Petrak J, Kuchař L, Kruger WD, Nagy P, Akaike T, Kožich V.
    Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial function.
    Redox Biol. 73: 103222 (2024)
  6. Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H.
    PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.
    Nat Metab. 6: 1108-1127 (2024)
  7. Fujita H, Tanaka YK, Ogata S, Suzuki N, Kuno S, Barayeu U, Akaike T, Ogra Y, Iwai K.
    PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.
    Nat Struct Mol Biol. 31: 1277-1285 (2024)
  8. Zhou L, Nishimura A, Umezawa K, Kato Y, Mi X, Ito T, Urano Y, Akaike T, Nishida M.
    Supersulfide catabolism participates in maladaptive remodeling of cardiac cells.
    J Pharmacol Sci. 155: 121-130 (2024) doi: 10.1016/j.jphs.2024.05.002.
  9. Kanemaru E, Shimoda K, Marutani E, Morita M, Miranda M, Miyazaki Y, Sinow C, Sharma R, Dong F, Bloch DB, Akaike T, Ichinose F.
    Exclusion of sulfide:quinone oxidoreductase from mitochondria causes Leigh-like disease in
    mice by impairing sulfide metabolism.
    J Clin Invest. 134: e170994 (2024)
  10. Hirai T, Ikeda-Imafuku M, Tasaka N, Tuan Giam Chuang V, Xian M, Ishida T, Akaike T, Ishima Y.
    Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides.
    Adv. Redox Res. 10: 100091 (2024)
  11. Cui Q, Shieh M, Pan TW, Nishimura A, Matsunaga T, Kelly SS, Xu S, Jung M, Ogata S, Morita M, Yoshitake J, Chen X, Robinson JR, Qian WJ, Nishida M, Akaike T, Xian M.
    2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and. increasing intracellular sulfane sulfur levels.
    Nat Commun. 15: 2453 (2024) doi: 10.1038/s41467-024-46652-7.
  12. Kakizawa S, Arasaki T, Yoshida A, Sato A, Takino Y, Ishigami A, Akaike T, Yanai S, Endo S.
    Essential role of ROS - 8-Nitro-cGMP signaling in long-term memory of motor learning and. cerebellar synaptic plasticity.
    Redox Biol. 70: 103053 (2024)
  13. Tsutsuki H, Zhang T, Akaike T, Sawa T.
    Regulation of innate immune and inflammatory responses by supersulfides.
    Int Immunol. 36: 143-154 (2024)
  14. Nishimura A, Yoon S, Matsunaga T, Ida T, Jung M, Ogata S, Morita M, Yoshitake J, Unno Y, Barayeu U, Takata T, Takagi H, Motohashi H, van der Vliet A, Akaike T.
    Longevity control by supersulfide-mediated mitochondrial respiration and regulation of. protein quality.
    Redox Biol. 69: 103018 (2024) doi: 10.1016/j.redox.2023.103018.
  15. Kasamatsu S, Kinno A, Miura C, Hishiyama JI, Fukui K, Kure S, Tsumura K, Ida T, Matsunaga T, Akaike T, Ihara H.
    Quantitative profiling of supersulfides naturally occurring in dietary meats and beans.
    Anal. Biochem. 685: 115392 (2024)
  16. Nishimura A, Tanaka T, Shimoda K, Ida T, Sasaki S, Umezawa K, Imamura H, Urano Y, Ichinose F, Kaneko T, Akaike T, Nishida M*.
    Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac. ischemia/reperfusion injury by preserving supersulfides.
    Redox Biol. 2024 Nov 28;79:103445. doi: 10.1016/j.redox.2024.103445.
  17. Atef Y, Ito T, Masuda A, Kato Y, Nishimura A, Kanda Y, Kunisawa J, Kusakabe T, Nishida M*.
    Diabetic Mice Spleen Vulnerability Contributes to Decreased Persistence of Antibody. Production after SARS-CoV-2 Vaccine.
    Int J Mol Sci. 2024 Sep 26;25(19):10379. doi: 10.3390/ijms251910379.
  18. Kondo M, Nakamura Y, Kato Y, Nishimura A, Fukata M, Moriyama S, Ito T, Umezawa K, Urano Y, Akaike T, Akashi K, Kanda Y, Nishida M*.
    Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS. cell-derived cardiomyocytes.
    J Pharmacol Sci. 2024 Oct 156(2), 69-76. doi: 10.1016/j.jphs.2024.07.007
  19. Kato Y, Ariyoshi K, Nohara Y, Matsunaga N, Shimauchi T, Shindo N, Nishimura A, Mi X, Kim SG, Ide T, Kawanishi E, Ojida A, Nakashima N, Mori Y, Nishida M*.
    Inhibition of dynamin-related protein 1-filamin interaction improves systemic glucose. metabolism.
    Br J Pharmacol. 2024 Jul 10. doi: 10.1111/bph.16487.
  20. Ariyoshi K, Nishiyama K, Kato Y, Mi X, Ito T, Azuma YT, Nishimura A, Nishida M*.
    Inhibition of Drp1-Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation. by Increasing Mitochondria-Lipid Droplet Contact.
    Int J Mol Sci. 2024 May 17;25(10):5446. doi: 10.3390/ijms25105446.
  21. Aoki H, Shinkai Y, Akiyama M, Yamazaki S, Nishida M, Kumagai Y.
    Extracellularly secreted cysteine derived from cystine regulates oxidative and electrophilic. stress in HepG2 cells.
    Free Radic Res. 2024 May 11:1-10. doi: 10.1080/10715762.2024.2350524.
  22. Yamada S, Hashita T, Yanagida S, Sato H, Yasuhiko Y, Okabe K, Noda T, Nishida M, Matsunaga T, Kanda Y.
    SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial. cells potentially by modulating the Wnt signaling pathway.
    Fluids Barriers CNS. 2024 Apr 8;21(1):32. doi: 10.1186/s12987-024-00533-9.
  23. Nishiyama K, Kato Y, Nishimura A, Mi X, Nagata R, Mori Y, Azuma YT, Nishida M*.
    Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.
    Int J Mol Sci. 2024 Feb 18;25(4):2401. doi: 10.3390/ijms25042401.
  24. Nishimura A*, Zhou L, Kato Y, Mi X, Ito T, Ibuki Y, Kanda Y, Nishida M*.
    Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and. cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation.
    J Pharmacol Sci. 2024 Feb;154(2):127-135. doi: 10.1016/j.jphs.2023.12.008.
  25. Xi Zheng, Takashi Toyama, Stephanie Siu, Takayuki Kaneko, Hikari Sugiura, Shota Yamashita, Yoshiteru Shimoda, Masayuki Kanamori, Kotoko Arisawa, Hidenori Endo, Yoshiro Saito.
    Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage.
    Scientific Reports, 14 (1), 682 (2024)DOI: https://doi.org/10.1038/s41598-024-51259-5
  26. Ryouhei Tsutsumi, Beatrix Ueberheide, Feng-Xia Liang, Benjamin G Neel, Ryuichi Sakai, Yoshiro Saito.
    Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation.
    Nature Communications, 15(1), 2843 (2024)
    DOI: https://doi.org/10.1038/s41467-024-46971-9
  27. Junya Ito, Toshitaka Nakamura, Takashi Toyama, Sebastian Doll, Mirai Suzuki, Weijia Zhang, Jiashuo Zheng, Dietrich Trümbach, Naoya Yamada, Koya Ono, Adam Wahida, Yoshiro Saito, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad.
    PRDX6 dictates ferroptosis sensitivity by directing cellular selenium mobilization.
    bioRxiv, 595693 (2024)DOI: https://doi.org/10.1101/2024.06.04.595693
  28. Christian Herder, Yoshiro Saito, Maria C Spagnuolo, Haifa Maalmi, Misaki Shimizu, Gidon J Bönhof, Keita Suzuki, Wolfgang Rathmann, Annette Peters, Michael Roden, Dan Ziegler, Barbara Thorand, Toshinari Takamura.
    Differential associations between selenoprotein P and distal sensorimotor polyneuropathy. in people with and without diabetes: KORA F4/FF4 study.
    Free Radical Biology and Medicine, 223, 87-95 (2024)
    DOI: https://doi.org/10.1016/j.freeradbiomed.2024.07.028
  29. Ryua Harima, Takahiro Sasaki, Takayuki Kaneko, Fuka Aso, Hayato Takashima, Takashi Toyama, Kenshiro Hara, Kentaro Tanemura, Yoshiro Saito.
    Ccdc152 is not necessary for male fertility, but contributes to maintaining sperm morphology.
    Journal of Reproduction and Development, 70(6), 396-404 (2024)　
    DOI: https://doi.org/10.1262/jrd.2024-058
  30. Kohei Matsuda, Yuichiro Mita, Kazumasa Saigoh, Yoshiro Saito, and Noriko Noguchi.
    Modifications of DJ-1 in which pI shifts to acidic in red blood cells a potential biomarker for. Parkinson’s disease at early stages.
    Free Radical Research, 58, 748-757 (2024)　
    DOI: https://doi.org/10.1080/10715762.2024.2430536
  31. Takashi Toyama, Katsuki Sato, Yoshiro Saito.
    Remodeling of Selenium Metabolism through Adduct Formation of Selenoprotein P with. Epigallocatechin Gallate.
    Metallomics Research, 4,3 (2024)　
    DOI: https://doi.org/10.11299/metallomicsresearch.MR202403
  32. Hayato Takashima, Takashi Toyama, Eikan Mishima, Kei Ishida, Yinuo Wang, Atsuya Ichikawa, Junya Ito, Syunsuke Yogiashi, Stephanie Siu, Mayumi Sugawara, Satoru Shiina, Kotoko Arisawa, Marcus Conrad, Yoshiro Saito.
    Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and. selenoprotein expression in cultured cells.
    The Journal of Toxicological Sciences, 49,12,555-563 (2024)　
    DOI: https://doi.org/10.2131/jts.49.555
  33. Junya Ito, Toshitaka Nakamura, Takashi Toyama, Sebastian Doll, Mirai Suzuki, Weijia Zhang, Jiashuo Zheng, Dietrich Trümbach, Naoya Yamada, Koya Ono, Adam Wahida, Yoshiro Saito, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad.
    PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization.
    Molecular Cell, 84, 23 (2024)　DOI: https://doi.org/10.1016/j.molcel.2024.10.028
  34. Yusuke Hirata, Yuto Yamada, Soma Taguchi, Ryota Kojima, Haruka Masumoto, Shinnosuke Kimura, Takuya Niijima, Takashi Toyama, Ryoji Kise, Emiko Sato, Yasunori Uchida, Junya Ito, Kiyotaka Nakagawa, Tomohiko Taguchi, Asuka Inoue, Yoshiro Saito, Takuya Noguchi, Atsushi Matsuzawa.
    Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic. degradation of GPX4 by targeting mitochondria.
    Cell Death & Disease, 84, 23 (2024)　DOI: https://doi.org/10.1038/s41419-024-07237-w
  35. Hayasaka K, Takeda H, Sakurada A, Matsumura Y, Abe J, Shiono S, Notsuda H, Suzuki H, Endo M, Motohashi H, Okada Y.
    Clinical, Genomic, and Transcriptomic Featurses of Lung Adenocarcinoma With. Uncommon EGFR Mutation.
    Clin Lung Cancer. 2024 Jan;25(1):e43-e51. doi: 10.1016/j.cllc.2023.10.006.
  36. Sekine H*, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H*.
    PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.
    Nat Metab. 2024 Jun;6(6):1108-1127. doi: 10.1038/s42255-024-01053-4.
  37. Himori K, Yamada M, Onoki T, Matsumaru D, Motohashi H, Okutsu M.
    Nrf2 deficiency in muscle attenuates experimental autoimmune myositis-induced muscle. weakness.
    J Physiol. J Physiol. 602 (22), 6189-6207, 2024. doi: 10.1113/JP286534.
  38. Tresky, R., Miyamoto, Y., Nagayoshi, Y., Yabuki, Y., Araki, K., Takahashi, Y., Komohara, Y., Ge, H., Nishiguchi, K., Fukuda, T., Kaneko, H., Maeda, N., Matsuura, J., Iwasaki, S., Sakakida, K., Shioda, N., Wei, F. Y., Tomizawa, K., & Chujo, T. (2024). TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Nucleic acids research, 52(15), 9230–9246.
  39. Ishikawa, K., Miyata, D., Hattori, S., Tani, H., Kuriyama, T., Wei, F. Y., Miyakawa, T., & Nakada, K.
    Accumulation of mitochondrial DNA with a point mutation in tRNALeu(UUR) gene. induces brain dysfunction in mice.
    Pharmacological research, 208, 107374. (2024).
  40. Matsuura, J., Akichika, S., Wei, F. Y., Suzuki, T., Yamamoto, T., Watanabe, Y., Valášek, L. S., Mukasa, A., Tomizawa, K., & Chujo, T.
    Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L. overexpression perturbs translation.
    Communications biology, 7(1), 1238. (2024).
  41. Oshima, H. S., Ogawa, A., Sano, F. K., Akasaka, H., Kawakami, T., Iwama, A., Okamoto, H. H., Nagiri, C., Wei, F. Y., Shihoya, W., & Nureki, O.
    Structural insights into the agonist selectivity of the adenosine A3 receptor.
    Nature communications, 15(1), 9294. (2024).
  42. *Funato Y, Mimura M, Nunomura K, Lin B, Fujii S, Haruta J, *Miki H.
    Development of a high-throughput screening system targeting the protein-protein. interactions between PRL and CNNM.
    Sci Rep. 2024 Oct 25;14(1):25432.
  43. Hashizume O, Kawabe T, Funato Y, *Miki H.
    Intestinal Mg2+ accumulation induced by cnnm mutations decreases the body size by. suppressing TORC2 signaling in Caenorhabditis elegans.
    Dev Biol. 2024 May;509:59-69.
  44. Sota Yamada, Eita Sasaki, Hisashi Ohno, Kenjiro Hanaoka
    “Heat-guided drug delivery via thermally induced crosslinking of polymeric micelles”
    Communications Chemistry, 7, 287 (2024).
  45. Mizuki Sugimoto, Eita Sasaki, Hisashi Ohno, Takayuki Ikeno, Sota Yamada, Kenjiro Hanaoka
    “Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric. Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)”
    Chemical and Pharmaceutical Bulletin, 72, 810-816 (2024).
  46. Kenjiro Hanaoka, Takayuki Ikeno, Shimpei Iwaki, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Fumiya Tao, Nobuhiko Kojima, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Kazuya Maeda, Hiroyuki Kusuhara, Yasuteru Urano
    “A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced. twisted intramolecular charge transfer (sr-TICT)”
    Science Advances, 10, eadi8847 (2024).
  47. Li X, Toyomoto T, Zhang T, Guo C, Lindahl S, Tsutsuki H, Xian M, Sawa T.
    Supersulphides suppress type-I and type-II interferon responses by blocking JAK/STAT. signalling in macrophages.
    Int Immunol. 2024 Nov 14;36(12):641-652. doi: 10.1093/intimm/dxae040.
  48. Lindahl S, Shieh M, Zhang T, Guo C, Robinson JR, Sawa T, Xian M.
    Thioglucose-derived tetrasulfide, a unique polysulfide model compound.
    Redox Biol. 2024 Apr;7 0:103045. doi: 10.1016/j.redox.2024.103045.
  49. C. Tsutsumi, K. Uegaki, R. Yamashita, R. Ushioda*, K. Nagata*:
    Zn²⁺-dependent functional switching of ERp18, an ER-resident thioredoxin-like protein, Cell Reports 43 (2): 113682 (2024)
  50. S. Iwamoto, R. Ushioda, N. Itano* et al.:
    Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation, Cell Death & Disease 15: 53 (2024)

2023年

  1. Sasama Y, Yoshimura K, Hoshino M, Sasa K, Akaike T, Morita M, Baba K, Shirota T, Miyamoto Y.
    Supersulfides support bone growth by promoting chondrocyte proliferation in the growth. plates.
    J. Oral. Biosci. 66: 76-81 (2023)
  2. Toyomoto T, Ono K, Shiba T, Momitani K, Zhang T, Tsutsuki H, Ishikawa T, Hoso K, Hamada K, Rahman A, Wen L, Maeda Y, Yamamoto K, Matsuoka M, Hanaoka K, Niidome T, Akaike T, Sawa T.
    Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of. drug-resistant Gram-negative bacteria to antibiotics.
    Front. Microbiol. 14: 1276447 (2023)
  3. Kasamatsu S, Owaki T, Komae S, Kinno A, Ida T, Akaike T, Ihara H.
    Untargeted polysulfide omics analysis of alternations in polysulfide production during the. germination of broccoli sprouts.
    Redox Biol. 67: 102875 (2023)
  4. Yang J, Sundqvist ML, Zheng X, Jiao T, Collado A, Tratsiakovich Y, Mahdi A, Tengbom J, Mergia E, Catrina SB, Zhou Z, Carlström M, Akaike T, Cortese-Krott MM, Weitzberg E, Lundberg JO, Pernow J.
    Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate. cyclase and release of cyclic GMP.
    J. Clin. Invest. 133: e167693 (2023)
  5. Ogata S, Matsunaga T, Jung M, Barayeu U, Morita M, Akaike T.
    Persulfide biosynthesis conserved evolutionarily in all organisms.
    Antioxid. Redox Signal. 39: 983-999 (2023)
  6. Kasamatsu S, Nishimura A, Alam MM, Morita M, Shimoda K, Matsunaga T, Jung M, Ogata S, Barayeu U, Ida T, Nishida M, Nishimura A, Motohashi H, Akaike T.
    Supersulfide catalysis for nitric oxide and aldehyde metabolism.
    Sci. Adv. 9: eadg8631 (2023) doi: 10.1126/sciadv.adg8631.
  7. Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, Numakura T, Ida T, Jung M, Ogata S, Yoon S, Fujino N, Kyogoku Y, Sasaki Y, Koarai A, Tamada T, Toyama A, Nakabayashi T, Kageyama L, Kyuwa S, Inaba K, Watanabe S, Nagy P, Sawa T, Oshiumi H, Ichinose M, Yamada M, Sugiura H, Wei FY, Motohashi H, Akaike T.
    Supersulphides provide airway protection in viral and chronic lung diseases.
    Nat. Commun. 14: 4476 (2023) doi: 10.1038/s41467-023-40182-4.
  8. Takeda H, Murakami S, Liu Z, Sawa T, Takahashi M, Izumi Y, Bamba T, Sato H, Akaike T, Sekine H, Motohashi H.
    Sulfur metabolic response in macrophage limits excessive inflammatory response by creating. a negative feedback loop.
    Redox Biol. 65: 102834 (2023) doi: 10.1016/j.redox.2023.102834.
  9. Tawarayama H, Umeki K, Inoue-Yanagimachi M, Takahashi N, Hasegawa H, Himori N, Tsuda S, Kunikata H, Akaike T, Nakazawa T.
    Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via. inhibition of proinflammatory cytokine production in glial cells.
    Sci. Rep. 13: 11513 (2023)
  10. Horii S, Sugawara H, Goto H, Hashimoto M, Matsunaga T, Akamatsu D, Tajima Y, Umetsu M, Akaike T, Kamei T.
    Presence of Helicobacter cinaedi in atherosclerotic abdominal aortic aneurysmal wall.
    Tohoku J. Exp. Med. 261: 35-41 (2023)
  11. Araki S, Takata T, Ono K, Sawa T, Kasamatsu S, Ihara H, Kumagai Y, Akaike T, Watanabe Y, Tsuchiya Y.
    Cystathionine γ-lyase self-inactivates by polysulfidation during cystine metabolism.
    Int. J. Mol. Sci. 24 :9982 (2023)
  12. Zhang T, Akaike T, Sawa T.
    Redox regulation of xenobiotics by reactive sulfur and supersulfide species.
    Antioxid. Redox Signal. 40: 679-690 (2023)
  13. Kinno A, Kasamatsu S, Akaike T, Ihara H.
    Reactive sulfur species omics analysis in the brain tissue of the 5xFAD mouse model of. Alzheimer's disease.
    Antioxidants 12: 1105 (2023)
  14. Hamid HA, Takata T, Matsunaga T, Akaike T.
    A persulfide shield: an endogenous reactive sulfur species in the forefront in the electrophile. detoxification pathway
    Sulfurtransferases -Essential enzymes for life foundations and frontiers in enzymology 101-107 (2023)
  15. Zainol Abidin QH, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, and Akaike T.
    Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes. in sulfur metabolism.
    Antioxidants 12: 868 (2023) doi: 10.3390/antiox12040868.
  16. Tang XK, Nishimura A, Ariyoshi K, Nishiyama K, Kato Y, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim HK, Han J, Kanda Y, Umezawa K, Urano Y, Akaike T, Nishida M.
    Echinochrome prevents sulfide catabolism-associated chronic heart failure after myocardial. infarction in mice.
    Marine Drugs 21: 51 (2023)
  17. Kasamatsu S, Kinno A, Hishiyama J, Akaike T, Ihara H.
    Development of methods for quantitative determination of the total and reactive. polysulfides: Reactive polysulfide profiling in vegetables
    Food Chem. 413: 135610 (2023)
  18. Alam MM, Kishino A, Sung E, Sekine H, Abe T, Murakami S, Akaike T, Motohashi H.
    Contribution of NRF2 to sulfur metabolism and mitochondrial activity
    Redox Biol. 60: 102624 (2023)
  19. Shimizu T, Ida T, Antelo GT, Ihara Y, Fakhoury JN, Masuda S, Giedroc DP, Akaike T, Capdevila DA, Masuda T.
    Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by. impacting intracellular polysulfide dynamics.
    PNAS Nexus 2: pgad048 (2023)
  20. Griffiths K, Ida T, Morita M, Lamb RJ, Lee JJ, Frenneaux MP, Fukuto JM, Akaike T, Feelisch M, Madhani M.
    Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial. ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?
    Redox Biol. 60: 102605 (2023)
  21. Takayuki Kaneko, Yuichiro Mita, Kanako Nozawa-Kumada, Masana Yazaki, Mieko Arisawa, Etsuo Niki, Noriko Noguchi, Yoshiro Saito.
    Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation.
    Free Radical Research, 56 (9-10), 677-690 (2023)　
    DOI: https://doi.org/10.1080/10715762.2023.2165918
  22. Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E. Steinberg, Yoshiro Saito, Atsushi Matsuzawa, Sergio Grinstein, and Spencer A. Freeman.
    Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to. execute ferroptosis.
    Current Biology, 33, 1282–1294 (2023)　DOI: https://doi.org/10.1016/j.cub.2023.02.060
  23. Kotoko Arisaw,Miyuki Kaneko, Ayumi Matsuoka, Natsuki Ozawa, Rie Kawawa, Tomoko Ishikawa, Ikuyo Ichi, Yoko Fujiwara.
    Piceatannol Prevents Obesity and Fat Accumulation Caused by Estrogen Deficiency in. Female Mice by Promoting Lipolysis.
    Nutrients, 15(6), 1374 (2023)　DOI: https://www.mdpi.com/2072-6643/15/6/1374
  24. Takashi Toyama, Sidi Xu, Yoshitomi Kanemitsu, Takashi Hasegawa, Takuya Noguchi, Jin-Yong Lee, Atsushi Matsuzawa, Akira Naganuma, Gi-Wook Hwang.
    Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth.
    Archives of Toxicology, 97, 1887–1897 (2023)　DOI: https://doi.org/10.1007/s00204-023-03520-5
  25. Marco Vinceti, Teresa Urbano, Annalisa Chiari, Tommaso Filippini, Lauren A. Wise, Manuela Tondelli, Bernhard Michalke, Misaki Shimizu, Yoshiro Saito.
    Selenoprotein P concentrations and risk of progression from mild cognitive impairment to. dementia.
    Scientific Reports, 13, 8792 (2023)　DOI: https://doi.org/10.1038/s41598-023-36084-6
  26. Ayako Mizuno, Takashi Toyama, Atsuya Ichikawa, Naoko Sakai, Yuya Yoshioka, Yukina Nishito, Renya Toga, Hiroshi Amesaka, Takayuki Kaneko, Kotoko Arisawa, Ryouhei Tsutsumi, Yuichiro Mita, Shun-Ichi Tanaka, Noriko Noguchi, Yoshiro Saito.
    An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity. ApoER2 receptor variant and being independent of selenocysteine lyase. .
    Journal of Biological Chemistry, 299, 105009 (2023)　
    DOI: https://doi.org/10.1016/j.jbc.2023.105009
  27. Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito.
    Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal. degradation independent of Nrf2.
    Commuications Biology, 6 (1), 2060 (2023)　
    DOI: https://doi.org/10.1038/s42003-023-05449-y
  28. Kotoko Arisawa, Ayumi Matsuoka, Natsuki Ozawa, Tomoko Ishikawa, Ikuyo Ichi, Yoko Fujiwara.
    GPER/PKA-Dependent Enhancement of Hormone-Sensitive Lipase Phosphorylation in 3T3-L1 Adipocytes by Piceatannol.
    Nutrients, 16(1), 38 (2023)　DOI: https://doi.org/10.3390/nu16010038
  29. Alam MM, Kishino A, Sung E, Sekine H, Abe T, Murakami S, Akaike T*, Motohashi H*.
    Contribution of NRF2 to Sulfur Metabolism and Mitochondrial Activity.
    Redox Biol 60, 102624, 2023. doi: 10.1016/j.redox.2023.102624.
  30. Takeda H, Nakajima Y, Yamaguchi T, Watanabe I, Miyoshi S, Nagashio K, Sekine H, Motohashi H, Yano H, Tanaka J.
    The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea. mediated by the activation of NRF2.
    J Biochem mvad030, 2023. doi: 10.1093/jb/mvad030.
  31. Ikeda R, Noshiro D, Morishita H, Takada S, Kageyama S, Fujioka Y, Funakoshi T, Komatsu-Hirota S, Arai R, Ryzhii E, Abe M, Koga T, Motohashi H, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura Y, Noda NN, Komatsu M.
    Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent. stress response.
    EMBO J. 2023 Jul 17;42(14): e113349. doi: 10.15252/embj.2022113349.
  32. Hayasaka K, Ohkouchi S, Saito-Koyama R, Suzuki Y, Okazaki K, Sekine H,Watanabe T, Motohashi H*, Okada Y*.
    Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and. impaired tissue repair response.
    Am J Transplant. 2023 Sep 19:S1600-6135(23)00692-5.
  33. Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M*, Inoue A*, Wei FY*.
    Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.
    Commun. Biol. 2023 May 12;6(1):511. doi: 10.1038/s42003-023-04888-x.
  34. Nishiyama K, Ariyoshi K, Nishimura A, Kato Y, Mi X, Kurose H, Kim SG, Nishida M*.
    Knockout of Purinergic P2Y6 Receptor fails to improve liver injury and inflammation in. non-alcoholic steatohepatitis.
    Int J Mol Sci. 2023 Feb 14;24(4):3800. doi: 10.3390/ijms24043800.
  35. Tang X, Nishimura A, Ariyoshi K, Nishiyama K, Kato Y, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim HK Han J, Kanda Y, Umezawa K, Urano Y, Akaike T, Nishida M*.
    Echinochrome prevents sulfide catabolism-associated chronic heart failure after myocardial. infarction in mice.
    Mar. Drugs 2023, 21, 52. https://doi.org/10.3390/md21010052.
  36. Tatsuya Ukegawa, Toru Komatsu, Mayano Minoda, Takuya Matsumoto, Takumi Iwasaka, Tadahaya Mizuno, Ryo Tachibana, Shingo Sakamoto, Kenjiro Hanaoka, Hiroyuki Kusuhara, Kazufumi Honda, Rikiya Watanabe, Yasuteru Urano
    “Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition”
    Advanced Science, 2306559 (2023).
  37. Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano
    “Discovery of a Cystathionine γ-Lyase (CSE) Selective Inhibitor Targeting Active-site Pyridoxal 5’-Phosphate (PLP) via Schiff Base Formation”
    Scientific Reports, 13, 16456 (2023).
  38. X. Cai, S. Ito, K. Noi, M. Inoue, R. Ushioda, Y. Kato, K. Nagata, K. Inaba*:
    Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by. cooperation between ERdj5 and BiP:
    J. Biol. Chem. 299 (11): 105274 (2023)
  39. K. Uegaki, Y. Tokunaga, M. Inoue, S. Takashima, K. Inaba, K. Takeuchi, R. Ushioda*, K. Nagata*:
    The oxidative folding of nascent polypeptides provides electrons for reductive reactions in. the ER,
    Cell Reports 42 (7): 112742 (2023)
  40. S. Fujii, R. Ushioda*, K. Nagata*:
    Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors,
    Proc. Natl. Acad. Sci. U.S.A. 120 (22): e2216857120 (2023)