国際共同研究加速基金 国際先導事業
レドックス超分子の生命機能解明に向けた
グローバルな研究先導
Global Exploration for Redox Supermolecules Evolving in Life Functions (G-ReXS)
Our Mission
Pioneering Redox Supermolecular Life Science and Fostering Future Leaders Through International Research Collaboration
Purpose of the G-ReXS Project
The aim of this project is to strengthen, expand, and promote the global network in the field of redox supermolecules science that has been cultivated by the principal investigator and collaborating researchers at domestic partner institutions. To achieve this, we will establish and broaden a robust framework for close international collaborations and researcher training, enabling long-term global development of the field.
Taking this project as an opportunity, we seek to integrate and deepen the academically diverse—but geographically dispersed—research efforts in redox supermolecules science worldwide, thereby creating the new discipline of Redox Supermolecules Life Science.
By strategically advancing global research co-creation from both academic and early-career researcher development perspectives, this project is expected to make significant contributions not only to life sciences, but also to basic and clinical medicine, ultimately promoting human health and well-being.
Background of G-ReXS
Redox reactions within living systems are governed by quantum-level electron energy dynamics. We have conceptualized this idea as a new framework called redox supermolecules and have actively advanced international collaborative research to develop the field. The term redox supermolecules refers collectively to substances that are universally present in nature and are dynamically produced and metabolized in living organisms, including oxygen molecules and reactive species such as reactive oxygen species and reactive nitrogen species.
Another class of redox supermolecules that has played a crucial role in driving the evolution of life on Earth is supersulfides. Recent international collaborative studies have, for the first time, demonstrated that supersulfides, which consist of linear chains of sulfur atoms, are produced in large quantities across diverse species and participate in a wide range of biological processes, including energy metabolism and the regulation of oxidative stress.
G-ReXS Research Framework
As a central hub for redox supermolecules research in Japan, we have established a liaison office at Tohoku University, led by Dr. Takaaki Akaike and colleagues who have long driven progress in this field. This hub will oversee and coordinate international activities conducted by domestic members, including the dispatch and training of graduate students and postdoctoral researchers abroad, as well as the management and operation of collaborative research initiatives.
Human Resource Development Plan
We plan to support long-term overseas assignments of 2–3 years for a total of 15 researchers, as well as short-term placements of three months for five researchers per year. In addition, up to 15 early-career researchers annually will receive support for short-term training, including participation in international conferences and related activities abroad. Regular web meetings will be held to maintain close communication between domestic and international laboratories, ensuring the efficient advancement of research and enabling rapid responses to unforeseen developments.
Support Plan for Independent Research by Early-Career Scientists
Early-career researchers who achieve outstanding research results will be encouraged to pursue his/her own projects and will receive financial support to advance their original work. We will also utilize young researcher support programs at each partner institution to provide opportunities and an environment for them to lead their own laboratories with independent, faculty-level positions. Through the development of a global network in redox supramolecular science, we aim to foster exceptional early-career researchers who will emerge as independent leaders in the field.